The rapid progress of genomic technologies has been providing new opportunities to address the need of maturity-onset diabetes of the young (MODY) molecular diagnosis. However. whether a new mutation causes MODY can be questionable. A number of in silico methods have been developed to predict functional effects of rare human mutations. https://www.diegojavierfares.com/quick-find-Umpqua-U203-U-Series-Hook-clearance/